Endocrine Abstracts

Introduction: A potential cause of panhypopituitarism could be cerebral tubercular lesions, that are often misdiagnosed. Hormonal effects could be related directly to primary tubercular lesions, or after starting antitubercular therapy. Paradoxical reaction (PR) in tuberculosis is defined as clinical or radiological worsening of pre-existing tuberculous lesions or development of new lesions after beginning an appropriate antitubercular therapy (ATT). It has been suggested that...

Introduction: Angiogenesis plays a major role in cancer growth and metastasis. Differences in angiogenesis and the balance of angiogenic growth factors and inhibitors may play a role in determining the observed variations in tumor behaviour. VEGF overexpression in adrenocortical carcinomas (AC) has been recently shown. Moreover a new steroidogenic specific tissue angiogenic factor (EG-VEGF) has been described, and its role is presently unknown in adrenal tumors. Previous evide...

In the diagnosis of Cushing’s disease (CD) desmopressin (dDAVP) stimulation test may be a convenient and more readily available alternative to CRH test; however the sensibility and specificity of ACTH response to dDAVP test has been reported in adult patients inferior to CRH test. In childhood patients with CD there are no data for the use of dDAVP test in this clinical setting. We studied 9 patients ranging in age from 11 to 19 years (7 females and 2 males) with a suspec...

Introduction: First-generation SRL (fg-SRL) represent the treatment of choice in acromegaly patients with post-neurosurgical adenomatous remnant and GH-hypersecretion. Anyway, approximately 60% of patients do not achieve adequate disease control. The main predictors of resistance include male sex, young age, invasiveness of the lesion and its hyperintensity on T2-weighted MRI scans; but also, SSTR2 expression, the cytokeratin pattern, Ki-67 and the presence of AIP gene mutatio...